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Abstract@#With the continuous growth in economics and science, physical activity in children and adolescents is gradually decreasing while the sedentary time, such as electronic video screen time, is increasing, which is defined as sedentary lifestyle. Research suggests that sedentary behavior, especially electronic video behavior, is harmful to all dimensions of children and adolescent’ health. Since 2016, the publication of international children’s and adolescents’ physical activity guideline has tended to be a 24-hour movement guideline with more comprehensive dimensions, detailed indicators and operationalities. However, the 24-hour movement guideline for children and adolescents still lacks sufficient evidence, and quite low target achievement rate, which seems to be an ideal goal for the vast majority of children. The purpose of this paper is to explore the current situation of physical activity and sedentary behavior of children and adolescents, as well as the development and evolution of comprehensive guideline. Through literature analysis, it focuses on the independent and combined effects of physical activity and sedentary behavior on children’s health, analyzes and implies the significance of 24-hour movement guideline for children and adolescents’ health, and provides inspiration and reference for future health promotion and behavior intervention among children and adolescents.
ABSTRACT
OBJECTIVE:To establish a method for the dissolubility determination of Manidipine Hydrochloride tablet and eval-uate the quality consistency of generic and original preparation. METHODS:HPLC was performed on the column of Waters Sym-metry C18 column with mobile phase of potassium phosphate monobasic solution (potassium phosphate monobasic 6.8 g was well-mixed with water 1 000 ml,and pH was adjusted to 4.6 by potassium hydroxide solution)-acetonitrile (49∶51,V/V) at flow rate of 1.0 ml/min,detection wavelength was 228 nm,column temperature was 25℃,and the injection volume was 20μl. The dis-solution mediums were 0.1 mol/L hydrochloric acid solution,acetic acid-sodium acetate buffer solution(pH 4.0)and phosphate buf-fer solution [pH 6.8,adding into 0.5% sodium dodecyl sulfonate(SDS)],volume of dissolution medium was 900 ml and rotating rate was 50 r/min,and the dissolubility of Manidipine hydrochloride tablet generic and original preparation was investigated and the similarity of dissolution profile was evaluated by calculating similar factor (f2). RESULTS:The linear range of manidipine hydro-chloride was 0.625-20 μg/ml;RSDs of instrument precision and stability tests were lower than 2.0%;recoveries of 3 dissolution mediums were 92.86%-102.97%(RSD=1.9%,1.8% and 2.7%,n=9),respectively. The dissolubility of 3 batches of Manidipine hydrochloride tablet generic and original preparations was higher than 85% in 0.1 mol/L hydrochloric acid solution in 15 min;f2 was >50 in acetic acid-sodium acetate buffer solution (pH 4.0) and phosphate buffer solution (pH 6.8,adding into 0.5% SDS). CONCLUSIONS:The method is suitable for the dissolubility determination of Manidipine hydrochloride tablet;meanwhile,the dis-solution profile in vitro of Manidipine hydrochloride tablet generic and original preparations has similarities,so the quality consis-tency is good.